Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Biol Lett
Prif Awduron: Hublarova, Pavla, Greplova, Kristina, Holcakova, Jitka, Vojtesek, Borivoj, Hrstka, Roman
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SP Versita 2010
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275699/
https://ncbi.nlm.nih.gov/pubmed/20526748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-010-0021-5
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