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Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases
Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhi...
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| Publicado no: | Cell Mol Biol Lett |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SP Versita
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6275699/ https://ncbi.nlm.nih.gov/pubmed/20526748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-010-0021-5 |
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