Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage. In an attempt to enhance the effects of these agents, we inhi...

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Bibliografiske detaljer
Udgivet i:Cell Mol Biol Lett
Main Authors: Hublarova, Pavla, Greplova, Kristina, Holcakova, Jitka, Vojtesek, Borivoj, Hrstka, Roman
Format: Artigo
Sprog:Inglês
Udgivet: SP Versita 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275699/
https://ncbi.nlm.nih.gov/pubmed/20526748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-010-0021-5
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