PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipocyte differentiation and is the target for the insulin-sensitizing thiazolidinedione (TZD) drugs used to treat type 2 diabetes. In cell-based in vitro studies, the transcriptional activity of PPAR...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Katafuchi, Takeshi, Holland, William L., Kollipara, Rahul K., Kittler, Ralf, Mangelsdorf, David J., Kliewer, Steven A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275522/
https://ncbi.nlm.nih.gov/pubmed/30420515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814522115
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