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Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative

The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Molecules
Prif Awduron: Szabó, Johanna, Jerkovics, Nóra, Schneider, Gyula, Wölfling, János, Bózsity, Noémi, Minorics, Renáta, Zupkó, István, Mernyák, Erzsébet
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273777/
https://ncbi.nlm.nih.gov/pubmed/27187336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21050611
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