Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer’s disease. The study describes synthesis and pharmacological evaluation of new compounds designed as dual binding site acetylcholinesterase inhibitors. Among the sy...

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Bibliographic Details
Published in:Molecules
Main Authors: Hebda, Michalina, Bajda, Marek, Więckowska, Anna, Szałaj, Natalia, Pasieka, Anna, Panek, Dawid, Godyń, Justyna, Wichur, Tomasz, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273065/
https://ncbi.nlm.nih.gov/pubmed/27023510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21040410
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