Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I...

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Publicado no:Molecules
Main Authors: Dgachi, Youssef, Bautista-Aguilera, Oscar M., Benchekroun, Mohamed, Martin, Hélène, Bonet, Alexandre, Knez, Damijan, Godyń, Justyna, Malawska, Barbara, Gobec, Stanislav, Chioua, Mourad, Janockova, Jana, Soukup, Ondrej, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273488/
https://ncbi.nlm.nih.gov/pubmed/27187348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21050634
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