Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer′s Disease Therapy

Herein we describe the synthesis and in vitro biological evaluation of thirteen new, racemic, diversely functionalized imidazo pyranotacrines as non-hepatotoxic, multipotent tacrine analogues. Among these compounds, 1-(5-amino-2-methyl-4-(1-methyl-1H-imidazol-2-yl)-6,7,8,9-tetrahydro-4H-pyrano[2,3-b...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Boulebd, Houssem, Ismaili, Lhassane, Bartolini, Manuela, Bouraiou, Abdelmalek, Andrisano, Vincenza, Martin, Helene, Bonet, Alexandre, Moraleda, Ignacio, Iriepa, Isabel, Chioua, Mourad, Belfaitah, Ali, Marco-Contelles, José
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273229/
https://ncbi.nlm.nih.gov/pubmed/27023499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21040400
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