Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules (MSM) for Alzheimer’s disease therapy. Contrary to our expectations, none of t...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bautista-Aguilera, Óscar M., Ismaili, Lhassane, Chioua, Mourad, Andrys, Rudolf, Schmidt, Monika, Bzonek, Petr, Martínez-Grau, María Ángeles, Beadle, Christopher D., Vetman, Tatiana, López-Muñoz, Francisco, Iriepa, Isabel, Refouvelet, Bernard, Musilek, Kamil, Marco-Contelles, José
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312762/
https://ncbi.nlm.nih.gov/pubmed/32486316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21113913
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