Highly Diastereoselective Synthesis of Spiropyrazolones

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Ceban, Victor, Olomola, Temitope O., Meazza, Marta, Rios, Ramon
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2015
Teme:
Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272153/
https://ncbi.nlm.nih.gov/pubmed/25985358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20058574
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