Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis

A stereoselective one-pot synthesis of spiropyrazolones through an organocatalytic asymmetric Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the in...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Hack, Daniel, Dürr, Alexander B, Deckers, Kristina, Chauhan, Pankaj, Seling, Nico, Rübenach, Lukas, Mertens, Lucas, Raabe, Gerhard, Schoenebeck, Franziska, Enders, Dieter
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2016
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725220/
https://ncbi.nlm.nih.gov/pubmed/26676875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510602
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