Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C-6 position. Dimerization of NAG-thiazoline via...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Krejzová, Jana, Šimon, Petr, Kalachova, Lubica, Kulik, Natallia, Bojarová, Pavla, Marhol, Petr, Pelantová, Helena, Cvačka, Josef, Ettrich, Rüdiger, Slámová, Kristýna, Křen, Vladimír
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271965/
https://ncbi.nlm.nih.gov/pubmed/24658571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19033471
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