Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner

Acute increases in O-linked β-N-acetylglucosamine (O-GlcNAc) levels of cardiac proteins exert protective effects against ischemia-reperfusion (I/R) injury. One strategy to rapidly increase cellular O-GlcNAc levels is inhibition of O-GlcNAcase (OGA), which catalyzes O-GlcNAc removal. Here we tested t...

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Detaylı Bibliyografya
Asıl Yazarlar: Laczy, Boglarka, Marsh, Susan A., Brocks, Charlye A., Wittmann, Istvan, Chatham, John C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2010
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993218/
https://ncbi.nlm.nih.gov/pubmed/20833964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00337.2010
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