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1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense, and cytotoxicity against L-6 cells in vitro. Furthermore, selectivity indices were a...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Wube, Abraham, Hüfner, Antje, Seebacher, Werner, Kaiser, Marcel, Brun, Reto, Bauer, Rudolf, Bucar, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271202/
https://ncbi.nlm.nih.gov/pubmed/25211002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules190914204
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