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Design, Synthesis and Anti-fibrosis Activity Study of N(1)-Substituted Phenylhydroquinolinone Derivatives
Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis. However, PFD is not active enough, requiring a...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6269057/ https://ncbi.nlm.nih.gov/pubmed/22301723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17021373 |
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