Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C(18) column (150 × 2.1 mm ID, 5 μm) was used...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Molecules
Main Authors: Li, Sha, Wang, Xingli, Peng, Kelong, Ma, Zhiguo, Zhang, Xiaoqi, Fu, Shaolian, Li, Xiaofei, Li, Linlin, Hong, Aihua, Jiang, Jie
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268535/
https://ncbi.nlm.nih.gov/pubmed/22391600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17032663
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