Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C(18) column (150 × 2.1 mm ID, 5 μm) was used...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Molecules
Hlavní autoři: Li, Sha, Wang, Xingli, Peng, Kelong, Ma, Zhiguo, Zhang, Xiaoqi, Fu, Shaolian, Li, Xiaofei, Li, Linlin, Hong, Aihua, Jiang, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2012
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268535/
https://ncbi.nlm.nih.gov/pubmed/22391600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17032663
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky