Rapid and Sensitive LC-MS/MS Method for the Determination of Metoprolol in Beagle Dog Plasma with a Simple Protein Precipitation Treatment and Its Pharmacokinetic Applications

A rapid LC-MS/MS method with good accuracy and sensitivity was developed and validated for the pharmacokinetics study of metoprolol (MP) in beagle dogs. The plasma samples were simply precipitated by methanol and then analyzed by LC-MS/MS. An Ultimate XB-C(18) column (150 × 2.1 mm ID, 5 μm) was used...

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Bibliografische gegevens
Gepubliceerd in:Molecules
Hoofdauteurs: Li, Sha, Wang, Xingli, Peng, Kelong, Ma, Zhiguo, Zhang, Xiaoqi, Fu, Shaolian, Li, Xiaofei, Li, Linlin, Hong, Aihua, Jiang, Jie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268535/
https://ncbi.nlm.nih.gov/pubmed/22391600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17032663
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