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Synthesis and Biological Evaluation of Thiophene Derivatives as Acetylcholinesterase Inhibitors

A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman’s method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Metho...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Ismail, Mohamed M., Kamel, Mona M., Mohamed, Lamia W., Faggal, Samar I., Galal, Mai A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268334/
https://ncbi.nlm.nih.gov/pubmed/22692245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17067217
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