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Synthesis and Biological Evaluation of Thiophene Derivatives as Acetylcholinesterase Inhibitors

A series of new thiophene derivatives has been synthesized using the Gewald protocol. The acetylcholinesterase inhibition activity was assayed according to Ellman’s method using donepezil as reference. Some of the compounds were found to be more potent inhibitors than the reference. 2-(2-(4-(4-Metho...

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Publicado en:Molecules
Autores principales: Ismail, Mohamed M., Kamel, Mona M., Mohamed, Lamia W., Faggal, Samar I., Galal, Mai A.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268334/
https://ncbi.nlm.nih.gov/pubmed/22692245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17067217
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