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Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1
Human flap endonuclease 1 (hFEN1) is a structure-specific nuclease essential for DNA replication and repair processes. hFEN1 has 5′ flap removal activity, as well as gap endonuclease activity that is critical for restarting stalled replication forks. Here, we report the crystal structures of wild-ty...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6265464/ https://ncbi.nlm.nih.gov/pubmed/30295841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky911 |
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