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Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1
Human flap endonuclease 1 (hFEN1) is a structure-specific nuclease essential for DNA replication and repair processes. hFEN1 has 5′ flap removal activity, as well as gap endonuclease activity that is critical for restarting stalled replication forks. Here, we report the crystal structures of wild-ty...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6265464/ https://ncbi.nlm.nih.gov/pubmed/30295841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky911 |
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