Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner

Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer types and is a marker for poor prognosis. To better understand the cellular consequences of FEN1 overexpression we utilized a model of its Saccharomyces cerevisiae homolog, RAD27. In this system, we discovered that...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Becker, Jordan R, Gallo, David, Leung, Wendy, Croissant, Taylor, Thu, Yee Mon, Nguyen, Hai Dang, Starr, Timothy K, Brown, Grant W, Bielinsky, Anja-Katrin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009675/
https://ncbi.nlm.nih.gov/pubmed/29741650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky313
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