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Trinucleotide repeat deletion via a unique hairpin bypass by DNA polymerase β and alternate flap cleavage by flap endonuclease 1

Trinucleotide repeat (TNR) expansions and deletions are associated with human neurodegenerative diseases and prostate cancer. Recent studies have pointed to a linkage between oxidative DNA damage, base excision repair (BER) and TNR expansion, which is demonstrated by the observation that DNA polymer...

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Autors principals: Xu, Meng, Gabison, Jonathan, Liu, Yuan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561997/
https://ncbi.nlm.nih.gov/pubmed/23258707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1306
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