Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment

The gene encoding the kinase Mnk2 (MKNK2) is alternatively spliced to produce two isoforms—Mnk2a and Mnk2b. We previously showed that Mnk2a is downregulated in several types of cancer and acts as a tumor suppressor by activation of the p38–MAPK stress pathway, inducing apoptosis. Moreover, Mnk2a ove...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Mogilevsky, Maxim, Shimshon, Odelia, Kumar, Saran, Mogilevsky, Adi, Keshet, Eli, Yavin, Eylon, Heyd, Florian, Karni, Rotem
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265459/
https://ncbi.nlm.nih.gov/pubmed/30329087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky921
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items