Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there are no inhibitors that directly inhibit the activity of SFs. We...

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Publicat a:Nat Commun
Autors principals: Denichenko, Polina, Mogilevsky, Maxim, Cléry, Antoine, Welte, Thomas, Biran, Jakob, Shimshon, Odelia, Barnabas, Georgina D., Danan-Gotthold, Miri, Kumar, Saran, Yavin, Eylon, Levanon, Erez Y., Allain, Frédéric H., Geiger, Tamar, Levkowitz, Gil, Karni, Rotem
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6453957/
https://ncbi.nlm.nih.gov/pubmed/30962446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09523-0
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