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Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms

The nucleolus, the site for ribosome biogenesis contains hundreds of proteins and several types of RNA. The functions of many non-ribosomal nucleolar proteins are poorly understood, including Surfeit locus protein 6 (SURF6), an essential disordered protein with roles in ribosome biogenesis and cell...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ferrolino, Mylene C., Mitrea, Diana M., Michael, J. Robert, Kriwacki, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265330/
https://ncbi.nlm.nih.gov/pubmed/30498217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07530-1
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