Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid phase separation (LLPS) via heterotypic interactions with nucleolar components, including ribosomal RNA (rRNA) and proteins wh...

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Foilsithe in:Nat Commun
Main Authors: Mitrea, Diana M., Cika, Jaclyn A., Stanley, Christopher B., Nourse, Amanda, Onuchic, Paulo L., Banerjee, Priya R., Phillips, Aaron H., Park, Cheon-Gil, Deniz, Ashok A., Kriwacki, Richard W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827731/
https://ncbi.nlm.nih.gov/pubmed/29483575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03255-3
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