Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

Nucleophosmin (NPM1) is an abundant, oligomeric protein in the granular component of the nucleolus with roles in ribosome biogenesis. Pentameric NPM1 undergoes liquid–liquid phase separation (LLPS) via heterotypic interactions with nucleolar components, including ribosomal RNA (rRNA) and proteins wh...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Mitrea, Diana M., Cika, Jaclyn A., Stanley, Christopher B., Nourse, Amanda, Onuchic, Paulo L., Banerjee, Priya R., Phillips, Aaron H., Park, Cheon-Gil, Deniz, Ashok A., Kriwacki, Richard W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827731/
https://ncbi.nlm.nih.gov/pubmed/29483575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03255-3
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