Structural polymorphism in the N-terminal oligomerization domain of NPM1

Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N-terminal oligomerization domain of NPM1 (Npm-N) exhibits structural polymorphism by populating conformational states ranging...

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Detalhes bibliográficos
Main Authors: Mitrea, Diana M., Grace, Christy R., Buljan, Marija, Yun, Mi-Kyung, Pytel, Nicholas J., Satumba, John, Nourse, Amanda, Park, Cheon-Gil, Madan Babu, M., White, Stephen W., Kriwacki, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970533/
https://ncbi.nlm.nih.gov/pubmed/24616519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321007111
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