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Intrinsically Unstructured Domains of Arf and Hdm2 Form Bi-molecular Oligomeric Structures In Vitro and In Vivo
Arf, Hdm2 and p53 regulate the tumor suppressor pathway that is most frequently disrupted in human cancer. In the absence of tumorigenic stress, Hdm2 actively attenuates p53-dependent cell cycle arrest and apoptosis by mediating ubiquitination-dependent degradation of p53. Mitogenic stress activates...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2612038/ https://ncbi.nlm.nih.gov/pubmed/18809412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.019 |
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