Long non-coding RNA MALAT1 suppresses breast cancer metastasis

MALAT1 has previously been described as a metastasis-promoting long non-coding RNA (lncRNA). Unexpectedly, we found that targeted inactivation of the Malat1 gene without altering the expression of its adjacent genes in a transgenic mouse model of breast cancer promoted lung metastasis, and important...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Kim, Jongchan, Piao, Hai-Long, Kim, Beom-Jun, Yao, Fan, Han, Zhenbo, Wang, Yumeng, Xiao, Zhenna, Siverly, Ashley N., Lawhon, Sarah E., Ton, Baochau N., Lee, Hyemin, Zhou, Zhicheng, Gan, Boyi, Nakagawa, Shinichi, Ellis, Matthew J., Liang, Han, Hung, Mien-Chie, You, M. James, Sun, Yutong, Ma, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265076/
https://ncbi.nlm.nih.gov/pubmed/30349115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0252-3
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