ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer

Although EZH2 enzymatic inhibitors have shown anti-tumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity. Here we identify ZRANB1 as the EZH2 deubiquitinase. ZRANB1...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Zhang, Peijing, Xiao, Zhenna, Wang, Shouyu, Zhang, Mutian, Wei, Yongkun, Hang, Qinglei, Kim, Jongchan, Yao, Fan, Rodriguez-Aguayo, Cristian, Ton, Baochau N., Lee, Minjung, Wang, Yumeng, Zhou, Zhicheng, Zeng, Liyong, Hu, Xiaoyu, Lawhon, Sarah E., Siverly, Ashley N., Su, Xiaohua, Li, Jia, Xie, Xiaoping, Cheng, Xuhong, Liu, Liang-Chiu, Chang, Hui-Wen, Chiang, Shu-Fen, Lopez-Berestein, Gabriel, Sood, Anil K., Chen, Junjie, You, M. James, Sun, Shao-Cong, Liang, Han, Huang, Yun, Yang, Xianbin, Sun, Deqiang, Sun, Yutong, Hung, Mien-Chie, Ma, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933875/
https://ncbi.nlm.nih.gov/pubmed/29669287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.078
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