Targeted Sequencing Identifies Missense variant in the BEST3 gene associated with Antihypertensive Response to Hydrochlorothiazide

Chromosome 12q15 was identified in Genetic Epidemiology of Response Assessment (GERA) and replicated in Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) for its association with blood pressure (BP) response to hydrochlorothiazide (HCTZ). However, the functional variant is unknown and...

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Pubblicato in:Pharmacogenet Genomics
Autori principali: Singh, Sonal, Wang, Zhiying, Shahin, Mohamed, Langaee, Taimour Y., Gong, Yan, Turner, Stephen T., Chapman, Arlene B., Gums, John G., McDonough, Caitrin W., Bailey, Kent R., Beitelshees, Amber L, Cooper-DeHoff, Rhonda M., Scherer, Steve, Boerwinkle, Eric, Johnson, Julie A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262886/
https://ncbi.nlm.nih.gov/pubmed/30289819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000353
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