A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia

Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts, therapeutic approaches to AML now feature the approved antibody drug conjugate (Mylotarg, GO) and investigational CART cell approaches incorporating C...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Schneider, Dina, Xiong, Ying, Hu, Peirong, Wu, Darong, Chen, Weizao, Ying, Tianlei, Zhu, Zhongyu, Dimitrov, Dimiter S., Dropulic, Boro, Orentas, Rimas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6262782/
https://ncbi.nlm.nih.gov/pubmed/30524966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00539
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