A tandem CD19/CD20 CAR lentiviral vector drives on-target and off-target antigen modulation in leukemia cell lines

BACKGROUND: Clinical success with chimeric antigen receptor (CAR)- based immunotherapy for leukemia has been accompanied by the associated finding that antigen-escape variants of the disease are responsible for relapse. To target hematologic malignancies with a chimeric antigen receptor (CAR) that t...

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Pubblicato in:J Immunother Cancer
Autori principali: Schneider, Dina, Xiong, Ying, Wu, Darong, Nӧlle, Volker, Schmitz, Sarah, Haso, Waleed, Kaiser, Andrew, Dropulic, Boro, Orentas, Rimas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433150/
https://ncbi.nlm.nih.gov/pubmed/28515942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-017-0246-1
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