SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis

SIRT1 is an NAD(+)‐dependent deacetylase that functions in a variety of cells and tissues to mitigate age‐associated diseases. However, it remains unknown if SIRT1 also acts to prevent pathological changes that accrue in motor neurons during aging and amyotrophic lateral sclerosis (ALS). In this stu...

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Опубликовано в: :Aging Cell
Главные авторы: Herskovits, Adrianna Z., Hunter, Tegan A., Maxwell, Nicholas, Pereira, Katherine, Whittaker, Charles A., Valdez, Gregorio, Guarente, Leonard P.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
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Original Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260920/
https://ncbi.nlm.nih.gov/pubmed/30295421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12839
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