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Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U.S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Curre...

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Библиографические подробности
Опубликовано в: :Molecules
Главные авторы: Li, Bing, Peet, Norton P., Butler, Michelle M., Burnett, James C., Moir, Donald T., Bowlin, Terry L.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6259422/
https://ncbi.nlm.nih.gov/pubmed/21193845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16010202
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