The E3 Ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Tumor metastasis is the primary cause of mortality in cancer patients and remains the major challenge for cancer therapy1. New therapeutic approaches to block inhibitory pathways of the immune system have renewed hopes for the utility of such therapies2. Here we show that genetic deletion of the E3...

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Udgivet i:Nature
Main Authors: Paolino, Magdalena, Choidas, Axel, Wallner, Stephanie, Pranjic, Blanka, Uribesalgo, Iris, Loeser, Stefanie, Jamieson, Amanda M., Langdon, Wallace Y., Ikeda, Fumiyo, Fededa, Juan P., Cronin, Shane J., Nitsch, Roberto, Schultz-Fademrecht, Carsten, Eickhoff, Jan, Menninger, Sascha, Unger, Anke, Torka, Robert, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Wolf, Dominik, Ullrich, Axel, Klebl, Bert M., Penninger, Josef M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258903/
https://ncbi.nlm.nih.gov/pubmed/24553136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12998
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