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Releasing the Brake: Targeting Cbl-b to Enhance Lymphocyte Effector Functions
The E3 ubiquitin ligase Cbl-b is an established nonredundant negative regulator of T-cell activation. Cbl-b fine-tunes the activation threshold of T cells and uncouples T cells from their vital need of a costimulatory signal to mount a productive immune response. Accordingly, mice deficient in cblb...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328896/ https://ncbi.nlm.nih.gov/pubmed/22550535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/692639 |
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