Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition

Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), a derivative of coumarin mainly found in plants of the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, fibrosis and tumor pr...

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Udgivet i:Front Physiol
Main Authors: Zhang, Suping, Huang, Qian, Cai, Xiaoxia, Jiang, Shan, Xu, Nan, Zhou, Qin, Cao, Xiaoyun, Hultström, Michael, Tian, Jiong, Lai, En Yin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258720/
https://ncbi.nlm.nih.gov/pubmed/30524310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01650
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