Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase

[Image: see text] Magnesium plays an important role in infection with Mycobacterium tuberculosis (Mtb) as a signal of the extracellular environment, as a cofactor for many enzymes, and as a structural element in important macromolecules. Raltegravir, an antiretroviral drug that inhibits HIV-1 integr...

詳細記述

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書誌詳細
出版年:J Med Chem
主要な著者: Oh, Sangmi, Park, Yumi, Engelhart, Curtis A., Wallach, Joshua B., Schnappinger, Dirk, Arora, Kriti, Manikkam, Michelle, Gac, Brian, Wang, Hongwu, Murgolo, Nicholas, Olsen, David B., Goodwin, Michael, Sutphin, Michelle, Weiner, Danielle M., Via, Laura E., Boshoff, Helena I. M., Barry, Clifton E.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257622/
https://ncbi.nlm.nih.gov/pubmed/30350998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00883
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