Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase

[Image: see text] Magnesium plays an important role in infection with Mycobacterium tuberculosis (Mtb) as a signal of the extracellular environment, as a cofactor for many enzymes, and as a structural element in important macromolecules. Raltegravir, an antiretroviral drug that inhibits HIV-1 integr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Med Chem
Autori principali: Oh, Sangmi, Park, Yumi, Engelhart, Curtis A., Wallach, Joshua B., Schnappinger, Dirk, Arora, Kriti, Manikkam, Michelle, Gac, Brian, Wang, Hongwu, Murgolo, Nicholas, Olsen, David B., Goodwin, Michael, Sutphin, Michelle, Weiner, Danielle M., Via, Laura E., Boshoff, Helena I. M., Barry, Clifton E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257622/
https://ncbi.nlm.nih.gov/pubmed/30350998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00883
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi