Discovery and Structure–Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2′-Oxidase

[Image: see text] Magnesium plays an important role in infection with Mycobacterium tuberculosis (Mtb) as a signal of the extracellular environment, as a cofactor for many enzymes, and as a structural element in important macromolecules. Raltegravir, an antiretroviral drug that inhibits HIV-1 integr...

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Bibliografische gegevens
Gepubliceerd in:J Med Chem
Hoofdauteurs: Oh, Sangmi, Park, Yumi, Engelhart, Curtis A., Wallach, Joshua B., Schnappinger, Dirk, Arora, Kriti, Manikkam, Michelle, Gac, Brian, Wang, Hongwu, Murgolo, Nicholas, Olsen, David B., Goodwin, Michael, Sutphin, Michelle, Weiner, Danielle M., Via, Laura E., Boshoff, Helena I. M., Barry, Clifton E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2018
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257622/
https://ncbi.nlm.nih.gov/pubmed/30350998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00883
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