Efflux Transporters Regulate Arsenite-Induced Genotoxicity in Double Negative and Double Positive T Cells

Arsenite (As(+3)) exposure is known to cause immunotoxicity in human and animal models. Our previous studies demonstrated that As(+3) at 50–500 nM concentrations induced both genotoxicity and nongenotoxicity in mouse thymus cells. Developing T cells at CD4-CD8- double negative (DN) stage, the first...

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Udgivet i:Toxicol Sci
Main Authors: Xu, Huan, Medina, Sebastian, Lauer, Fredine T., Douillet, Christelle, Liu, Ke Jian, Hudson, Laurie G., Stýblo, Miroslav, Aleksunes, Lauren M., Burchiel, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Efflux Transporters and Arsenite Genotoxicity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6257016/
https://ncbi.nlm.nih.gov/pubmed/28472378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx075
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