Environmentally Relevant Concentrations of Arsenite and Monomethylarsonous Acid Inhibit IL-7/STAT5 Cytokine Signaling Pathways in Mouse CD3+CD4−CD8− Double Negative Thymus Cells

Environmental arsenic exposure is a public health issue. Immunotoxicity induced by arsenic has been reported in humans and animal models. The purpose of this study was to evaluate mechanisms of As(+3) and MMA(+3) toxicity in mouse thymus cells. Because we know that MMA(+3) inhibits IL-7 signaling in...

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Veröffentlicht in:Toxicol Lett
Hauptverfasser: Xu, Huan, Lauer, Fredine T., Liu, Ke Jian, Hudson, Laurie G., Burchiel, Scott W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792750/
https://ncbi.nlm.nih.gov/pubmed/26921788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2016.02.014
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