Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells

Inhibition of DNA repair and oxidative stress are 2 common mechanisms associated with arsenic-induced genotoxicity. The purpose of this study was to examine mechanisms of genotoxicity induced by environmentally relevant doses of arsenite (As(+3)) in mouse thymus cells. An increase in DNA damage and...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Xu, Huan, Zhou, Xixi, Wen, Xia, Lauer, Fredine T., Liu, Ke Jian, Hudson, Laurie G., Aleksunes, Lauren M., Burchiel, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Arsenite and Parp-Related Genotoxicity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715257/
https://ncbi.nlm.nih.gov/pubmed/26443841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv211
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