Rivaroxaban and macitentan can be coadministered without dose adjustment but the combination of rivaroxaban and St John's wort should be avoided

AIMS: We assessed the potential mutual interaction of oral macitentan (cytochrome P450 (CYP) 3A4 substrate) at steady‐state with single‐dose oral rivaroxaban (CYP3A4 and P‐glycoprotein substrate) and evaluated the effect of the CYP3A and P‐glycoprotein inducer St John's wort (SJW) on the pharma...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Huppertz, Andrea, Werntz, Lars, Meid, Andreas D., Foerster, Kathrin I., Burhenne, Jürgen, Czock, David, Mikus, Gerd, Haefeli, Walter E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255992/
https://ncbi.nlm.nih.gov/pubmed/30192025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13757
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