706. Ceftazidime-Avibactam (CZA) and Meropenem (MER) Are Synergistic and Bactericidal Against Genetically Diverse KPC-Producing Klebsiella pneumoniae (Kp)

BACKGROUND: We previously showed that CZA MICs are higher among KPC-3 Kp and KPC-2 Kp with porin mutations. Clinical resistance has emerged among KPC-3 Kp. Here, we tested various agents in combination with CZA for synergistic and bactericidal activity. METHODS: We tested isolates for responses to C...

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Publicado no:Open Forum Infect Dis
Main Authors: Jones, Chelsea, Kline, Ellen, Morder, Kristin, Clancy, Cornelius J, Nguyen, M Hong, Shields, Ryan K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6253474/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.713
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