In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases

Ceftazidime-avibactam resistance is mediated by bla(KPC-3) mutations, which restore carbapenem susceptibility. We subjected Klebsiella pneumoniae isolates with different bla(KPC-3) mutations (n = 5) or wild-type bla(KPC-3) (n = 2) to serial passages with meropenem. The meropenem MIC against each iso...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Shields, Ryan K., Nguyen, M. Hong, Press, Ellen G., Chen, Liang, Kreiswirth, Barry N., Clancy, Cornelius J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404588/
https://ncbi.nlm.nih.gov/pubmed/28242667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00079-17
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