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Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway
The design of efficient therapies for age-related macular degeneration (AMD) is limited by our understanding of the pathogenesis of basal deposits, which form between retinal pigment epithelium (RPE) and Bruch’s membrane (BrM) early in disease, and involve activation of the complement system. To inv...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6251553/ https://ncbi.nlm.nih.gov/pubmed/29095988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx392 |
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