Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation....

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Vydáno v:Genome Biol
Hlavní autoři: Van den Berge, Koen, Perraudeau, Fanny, Soneson, Charlotte, Love, Michael I., Risso, Davide, Vert, Jean-Philippe, Robinson, Mark D., Dudoit, Sandrine, Clement, Lieven
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Method
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251479/
https://ncbi.nlm.nih.gov/pubmed/29478411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1406-4
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