Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation....

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Veröffentlicht in:Genome Biol
Hauptverfasser: Van den Berge, Koen, Perraudeau, Fanny, Soneson, Charlotte, Love, Michael I., Risso, Davide, Vert, Jean-Philippe, Robinson, Mark D., Dudoit, Sandrine, Clement, Lieven
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Method
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251479/
https://ncbi.nlm.nih.gov/pubmed/29478411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1406-4
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