Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications

Dropout events in single-cell RNA sequencing (scRNA-seq) cause many transcripts to go undetected and induce an excess of zero read counts, leading to power issues in differential expression (DE) analysis. This has triggered the development of bespoke scRNA-seq DE methods to cope with zero inflation....

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Van den Berge, Koen, Perraudeau, Fanny, Soneson, Charlotte, Love, Michael I., Risso, Davide, Vert, Jean-Philippe, Robinson, Mark D., Dudoit, Sandrine, Clement, Lieven
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251479/
https://ncbi.nlm.nih.gov/pubmed/29478411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1406-4
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